The most serious, life changing, choices are never black and white no-brainers. They require decisions like about what job to take or leave, who and when to marry or divorce, whether to have a baby, and whether to give up material pursuits for spiritual pursuits.
Some argue that any decision or choice you make is life changing. Jean-Paul Sartre says "We are our Choices." What we choose to do sets off a chain reaction that affects our future and the future of others. It is the law of karma - what we do colors our mind and causes effects into the future. Consider the decision to give a dollar to a homeless person. How does it change you? How does it change the homeless person?