It is far more effective to respond than to react. To respond implies thinking about actions and their outcomes. To react implies action without thought.
People face psychological crises, some large and some small, at various points in their lives. The crises may include things like feeling dissatisfied with personal accomplishments, no matter how many there are and the way others perceive them, or feeling dissatisfied with a current work or life situation, seeking to "remake themselves" while feeling that it is too late or too costly to do so. Other common crises are over relationship issues, for example, whether a partner was the right choice or not even after decades together.